Resting metabolic rate is increased in hypertensive patients with overweight or obesity: Potential mechanisms

The purpose of this investigation was to determine whether differences in body composition, pharmacological treatment, and physical activity explain the increased resting metabolic rate (RMR) impaired insulin sensitivity hypertension. Resting blood pressure, RMR (indirect calorimetry), composition (dual-energy X-ray absorptiometry), (accelerometry), maximal oxygen uptake (VO2max) (ergospirometry), (Matsuda index) were measured 174 patients (88 men 86 women; 20–68 years) with overweight or obesity. Hypertension (HTA) present 51 (58%) 42 women (49%) (p = .29). 6.9% higher hypertensives than normotensives (1777 ± 386 1663 383 kcal d−1, p .044). double product (systolic pressure × heart rate) 18% hypertensive normotensive < .001). observed absolute non-significant after adjusting for total lean mass fat (estimated means: 1702 CI: 1656–1750; 1660 1611–1710 groups, respectively, .19, HTA sex interaction .37). Lean mass, product, age variables predictive value patients. Insulin lower patients, but these disappeared accounting VO2max. In summary, hypertension is associated reduced sensitivity. explained by an elevated myocardial consumption due combined between subjects.